I just finished reading an article in The New Republic which argues that history and the humanities are knowledge too. At times it felt like the author was yelling at his brother begging to be noticed. Personally, I feel that in general the author is correct, that history and humanities do plan an important role and can be considered as knowledge. However, the author makes one glaring mistake, he is equating the unified theories of everything in physics with everything, where it typically means a combination of all physical laws within physics both particle and cosmic, which would then move into chemistry and likely into biology. However, this type of theory of everything would stop there. It couldn't really combine natural selection as functions of chemicals in a specific manager do not necessarily mean a truer understanding of evolution. It would be able to explain how phenotypes are changed with genotypes, but not why one genotype/phenotype pair was selected over another without an understanding of the specifics of the environments at a time. A true theory of everything at that level would essentially be a simulation of the universe. It would be impossible to model in a series of equations beyond the fundamental laws of physics.
For the evolution of biological systems you have to understand the natural history of the world that the organisms develop and evolve. This is why when you read Sagan, Dawkins or any other biologists or cosmologist they argue that if you rewound the tape of history you'd get a different present day. Some things may have happened just slightly different enough and you'd have no humans. The understanding of the history of our world allows us to understand where the future of it is going.
In the same way, history does matter. There are branches of economics, such as evolutionary economics that use complexity models and work to ensure that the history of events are included in their models. What the major difference between typical theories of history and psychology and newer models of economics and complex systems of physics, is that we're able to test them using simulations. It is likely that in the future we'll be able to do the same thing with history. This will give us a deeper understanding of why our societies have developed as they have. One heavily contested aspect of evolution, which is mentioned in the article, is cultural inheritance, which is where the theory of memes came from. This approach doesn't suggest one type of people is better than another or one lifestyle is better than another, it simply says that in the environment that the culture resides it's more capable of surviving than others. This can go down deeper to smaller niches within the culture and how well they adapt to their environment.
Other aspects the author argues discusses is the differences in the acceptability (or perhaps the perception) of radical paradigm shifts in science compared to the humanities and history. He mentioned specifically Freud in psychology and Galileo in physics. He argues that Galileo was able to make changes in physics because he tackled an "easy" problem that had minimal level of complexity. He went after the theory of gravity and how objects fall at the same rate while Freud went after the entirety of the human psyche. I agree there is a difference of complexity, however the key differences between Galileo and Freud is that he was better able to explain the state of the world and when new scientific theories were produced they continued to explain what Galileo found but with more accuracy and expanded on them. When Freud was discredited it was more like discrediting Alchemy than going from Newtonian physics to Relativistic physics.
The key difference between many theories in humanities and in the rest of science is the lack of continuum between two major theories. Yes, Relativistic physics completely obliterated the value of Newtonian physics and created a new world (universe) view, but it solved the same problems or proved that many of the old problems were only problems because the theory wasn't complete enough.
The key that needs to be remembered in either science or humanities is that all models are wrong, but some are useful. Freud was wrong in how he looked at the human psyche, but his models allowed other theories to be tested and used and likely spawned Neuroscience and the bridging between neuroscience and many of psychological problems.
I am constantly reading articles about Science, Technology, copyright, and various other topics. I've decided to post my thoughts on different ideas related to these topics.
Showing posts with label Philosophy of Science. Show all posts
Showing posts with label Philosophy of Science. Show all posts
Saturday, May 12, 2012
Thursday, February 23, 2012
The difficulty of science
As reported in Science Insider yesterday, apparently the faster than light neutrinos may have been caused by a loose fiber optics cable. To me this also begs the question, were other results impacted by this loose fiber opitc cable?
This is where the difficulty in science lies. First, CERN had to admit that there was a faulty detector which could have caused the result invalidating what likely was the greatest finding in physics recently. Secondly, they are going to have to run the same tests again to make sure the results were bad. Finally, a bunch of other locations invested in their capabilities and will be able to test the results for themselves too. I think the last two are important. At one point Fermi lab indicated that they had seen faster than light neutrinos but it was beyond their capabilities to reach the required level of statistical significance.
I think that this does show an important factor within science. First, scientists have the ability to referee themselves on important earth (speed of light) shattering results. It indicates that the system works. Secondly, it shows there is integrity in scientists, as something like this essentially will make careers and set this group up for the rest of their lives somewhere. As they admitted what caused the error and are working to correct it in testing, it indicates they care more about the results than about their career. Although, lying about this after finding it would have ruined their careers just as quickly.
Why is that important though? Let's take a step back and look at the bigger picture. Most scientists are trained in a very similar fashion. You are taught the basics during high school, moving to more advanced topics in college and finally many become experts by pursuing a PhD. All are taught about the idea of falsifiablity of hypothesis and theories as the cornerstone for scientific progress. Of course there are debates of if this is how things actually work in science, but typically it is. There are points where a major shift in scientific discourse but this can take a long time and must answer questions of the previous scientific perspective and answer questions the other perspective could not. A perfect example of this is Newtonian physics and Relativistic physics. Newtonian physics gives you Force = Mass x Acceleration, it's not really fully accurate, but it works well enough for daily activity. Under certain circumstances it's simply wrong. That's where Einstein came in and fixed it. It took a while for the shift of acceptance for this theory, but it's now the prevailing theory.
From a scientists point of view their incentives are oriented towards yearly output of papers that are accepted into high quality peer reviewed journals, such as Science and Nature and whatever is the best in their field. There are no incentives for making hoax theories. They would lose funding and eventually be jobless.
I think that this error at CERN can bring that into the discourse over topics such as evolution and climate change. It's indicative of the ethics that prevail in science today and that when theories are wrong work is done to find out why or how. Once that has been answered, new theories are suggested and eventually accepted. Understanding how this works will make topics like climate change and evolution less threatening.
This is where the difficulty in science lies. First, CERN had to admit that there was a faulty detector which could have caused the result invalidating what likely was the greatest finding in physics recently. Secondly, they are going to have to run the same tests again to make sure the results were bad. Finally, a bunch of other locations invested in their capabilities and will be able to test the results for themselves too. I think the last two are important. At one point Fermi lab indicated that they had seen faster than light neutrinos but it was beyond their capabilities to reach the required level of statistical significance.
I think that this does show an important factor within science. First, scientists have the ability to referee themselves on important earth (speed of light) shattering results. It indicates that the system works. Secondly, it shows there is integrity in scientists, as something like this essentially will make careers and set this group up for the rest of their lives somewhere. As they admitted what caused the error and are working to correct it in testing, it indicates they care more about the results than about their career. Although, lying about this after finding it would have ruined their careers just as quickly.
Why is that important though? Let's take a step back and look at the bigger picture. Most scientists are trained in a very similar fashion. You are taught the basics during high school, moving to more advanced topics in college and finally many become experts by pursuing a PhD. All are taught about the idea of falsifiablity of hypothesis and theories as the cornerstone for scientific progress. Of course there are debates of if this is how things actually work in science, but typically it is. There are points where a major shift in scientific discourse but this can take a long time and must answer questions of the previous scientific perspective and answer questions the other perspective could not. A perfect example of this is Newtonian physics and Relativistic physics. Newtonian physics gives you Force = Mass x Acceleration, it's not really fully accurate, but it works well enough for daily activity. Under certain circumstances it's simply wrong. That's where Einstein came in and fixed it. It took a while for the shift of acceptance for this theory, but it's now the prevailing theory.
From a scientists point of view their incentives are oriented towards yearly output of papers that are accepted into high quality peer reviewed journals, such as Science and Nature and whatever is the best in their field. There are no incentives for making hoax theories. They would lose funding and eventually be jobless.
I think that this error at CERN can bring that into the discourse over topics such as evolution and climate change. It's indicative of the ethics that prevail in science today and that when theories are wrong work is done to find out why or how. Once that has been answered, new theories are suggested and eventually accepted. Understanding how this works will make topics like climate change and evolution less threatening.
Friday, September 30, 2011
Future of Employment II
Yesterday I talked a little bit about the future of employment. Apparently this isn't the most interesting topic. However, it's important. The Slate series ends with some startling research that shows even scientists could eventually be replaced. I think we are a long way from those things happening. In my opinion the first things that machines will do in R&D is replace humans in the creation of incremental innovations. In fact, to some extent computers already do replace humans in some of these things. Computers do a great deal of CPU, DRAM and Flash designing. Typically, these are incremental innovations. They are building on a current technology and making improvements. Humans are required for the radical innovations, such as a new chip set, calculation methodology or what have you.
Even some advanced R&D work could easily be improved by computers. Researchers have to read a great deal of papers to keep up with the state of the art in research. As the slate series points out, this is a form of data mining and lawyers are currently using automated programs to find specific words. There's actually a branch of Science and Technology Studies that focuses on word analysis. They use similar programs and dump a few papers into it and figure out what verbal connections between the papers exist. This is a way of creating maps of knowledge. You are able to see through citations and similar word usage that a specific theory is prevalent or not. How would this apply to R&D? You could put in the materials that you're using the problems you're seeing and a bunch of papers that might be related and see what comes out. It could give you new materials new designs things of this nature. For this to work though, it's a ways away.
What does mean in the long run? That no position is safe. I don't think this will happen in our life time though. People are much too conservative to leave everything to computers. They just simply won't be accepted. Even by our generation there's too much distrust. It's going to take one or two more generations for there to be enough trust in computing and technology to allow more control to shift to them. Sure some companies will be on the cutting edge with accepting these changes, others will be laggers.
If computers can do everything why do we need any jobs, isn't the guy from CNN is right? I disagree. People will always want to work. People need to work. I'm not saying this because I'm hoping there won't be a robotic take over or anything, but because people will not allow it to happen. In general people like to feel in control. Even if you aren't the bus driver, knowing that it's a person that you can relate to makes you feel like your more in control. Leaving everything to computers requires a level of surrender. Many people will simply refuse to give up that level of control. We won't have fancy automatically driving cars for this very reason. People love to feel in control of where they go. It doesn't matter if they would be safer, save money and get places faster. They would rail against the change because they loose control.
Would we leave the future of our economy in the hands of machines? You could argue that some companies already have. For instance take the May flash crash on Wall street. This has been attributed to high frequency trading following logical algorithms, it wiped about $1 trillion in wealth, most of it was restored.
In much of my research on academic spin-offs and technology incubators there is an important component related to tacit knowledge. Know how of the inventor of a technology. This is something that we'd lose if all of our work was robotized. There's no difference in that than outsourcing. In developmental economics and innovation theories the ability to create copycat technologies is a precursor to developing their own technologies in that field. I think this is something we must keep in mind when discussing the reality of full automation. Without tacit knowledge and hands on experience with the devices and machines building the product it's very difficult to develop improvements on either.
I think that we'll have many legacy jobs hanging around for a long time. Simply because we need them to continue growing economically. Otherwise, we'll stagnate and keep producing the same technologies.
Even some advanced R&D work could easily be improved by computers. Researchers have to read a great deal of papers to keep up with the state of the art in research. As the slate series points out, this is a form of data mining and lawyers are currently using automated programs to find specific words. There's actually a branch of Science and Technology Studies that focuses on word analysis. They use similar programs and dump a few papers into it and figure out what verbal connections between the papers exist. This is a way of creating maps of knowledge. You are able to see through citations and similar word usage that a specific theory is prevalent or not. How would this apply to R&D? You could put in the materials that you're using the problems you're seeing and a bunch of papers that might be related and see what comes out. It could give you new materials new designs things of this nature. For this to work though, it's a ways away.
What does mean in the long run? That no position is safe. I don't think this will happen in our life time though. People are much too conservative to leave everything to computers. They just simply won't be accepted. Even by our generation there's too much distrust. It's going to take one or two more generations for there to be enough trust in computing and technology to allow more control to shift to them. Sure some companies will be on the cutting edge with accepting these changes, others will be laggers.
If computers can do everything why do we need any jobs, isn't the guy from CNN is right? I disagree. People will always want to work. People need to work. I'm not saying this because I'm hoping there won't be a robotic take over or anything, but because people will not allow it to happen. In general people like to feel in control. Even if you aren't the bus driver, knowing that it's a person that you can relate to makes you feel like your more in control. Leaving everything to computers requires a level of surrender. Many people will simply refuse to give up that level of control. We won't have fancy automatically driving cars for this very reason. People love to feel in control of where they go. It doesn't matter if they would be safer, save money and get places faster. They would rail against the change because they loose control.
Would we leave the future of our economy in the hands of machines? You could argue that some companies already have. For instance take the May flash crash on Wall street. This has been attributed to high frequency trading following logical algorithms, it wiped about $1 trillion in wealth, most of it was restored.
In much of my research on academic spin-offs and technology incubators there is an important component related to tacit knowledge. Know how of the inventor of a technology. This is something that we'd lose if all of our work was robotized. There's no difference in that than outsourcing. In developmental economics and innovation theories the ability to create copycat technologies is a precursor to developing their own technologies in that field. I think this is something we must keep in mind when discussing the reality of full automation. Without tacit knowledge and hands on experience with the devices and machines building the product it's very difficult to develop improvements on either.
I think that we'll have many legacy jobs hanging around for a long time. Simply because we need them to continue growing economically. Otherwise, we'll stagnate and keep producing the same technologies.
Tuesday, September 27, 2011
Frivolous Science? Pfft
Today I saw this post on Reddit. Long story short this guy was asking the r/askscience subreddit why we do research like the CERN experiments, as it has no practical use. There are several reasons. I've mentioned some of these on here before, but they can always be mentioned again. First, research that we conduct now that is interesting only to a small subset of people may be applied for other things later. Second, furthering our understanding of the world isn't frivolous. Third, in many cases basic research must be completed at universities because industry will not pay for it.
Some examples, bird migration research that told us a lot about birds historically probably wasn't very interesting to much of the scientific community. However, it's become more important of late. One of my friends commented to me about how in Europe during the Avian flu, migration patterns became extremely important for predicting where the next could be. There are further uses, those migration patterns are being used to determine where to place wind mills, because we don't want to put a wind farm in the middle of a bird migration path. The slaughter would be horrifying. Finally, changes in migration patterns may represent a shift in local climates. If birds take longer to migrate south, it indicates that the weather isn't changing as fast as it used to. Over time this data could indicate a trend and we should look for further evidence of climate change.
In 2009 there was a rash of articles that questioned the importance of scientific research in some cases. This isn't really new, even at that point there'd been the infamous McCain bear comments. Even scientists make fun of some of the more obscure types of research with the Ig Noble Awards (One award was given to a research that only cracked the knuckles on one hand to test for arthritis differences (there wasn't any)). Despite this, some of this research is interesting and could be useful in the future. Take the recent finding that fish are angry in boring fish tanks. This research is pretty much useless unless you're a fish fan. However, it also shows us that we clearly don't understand animals as well as we think we do. Even popular stories about the memory span of gold fish was shown to be wrong by the MythBusters. These examples indicate that many people don't understand the importance of research and that even scientists don't. However, even seemingly pointless research can illuminate our understanding of the world. People love to know nearly pointless facts. This also ties back to the my first point above, we never know when something seemingly useless can suddenly have an importance beyond the scope of the original study. It may save lives. That finding about fishes could help build better large scale aquariums where it is safer to interact with dangerous fish, like killer whales and sharks.
My final point is that some basic research will not be conducted by industry players. There's no guarantee on any return on some scientific investigation. However, it can be incredibly important for the advancement of industry. Quantum computing could be the next big thing for computing, however it's being researched by a combination of industry and universities. Most of the money and risk is on the university side though. Our understanding of particle physics helps us understand how quantum computing can help. Eventually we may be able to use this neutrino finding, if it pans out, in communication systems. There's no reason why we wouldn't be able to use the spin of a neutrino to transmit information.
Seemingly frivolous research is an important part of the scientific process. Enjoy it.
Some examples, bird migration research that told us a lot about birds historically probably wasn't very interesting to much of the scientific community. However, it's become more important of late. One of my friends commented to me about how in Europe during the Avian flu, migration patterns became extremely important for predicting where the next could be. There are further uses, those migration patterns are being used to determine where to place wind mills, because we don't want to put a wind farm in the middle of a bird migration path. The slaughter would be horrifying. Finally, changes in migration patterns may represent a shift in local climates. If birds take longer to migrate south, it indicates that the weather isn't changing as fast as it used to. Over time this data could indicate a trend and we should look for further evidence of climate change.
In 2009 there was a rash of articles that questioned the importance of scientific research in some cases. This isn't really new, even at that point there'd been the infamous McCain bear comments. Even scientists make fun of some of the more obscure types of research with the Ig Noble Awards (One award was given to a research that only cracked the knuckles on one hand to test for arthritis differences (there wasn't any)). Despite this, some of this research is interesting and could be useful in the future. Take the recent finding that fish are angry in boring fish tanks. This research is pretty much useless unless you're a fish fan. However, it also shows us that we clearly don't understand animals as well as we think we do. Even popular stories about the memory span of gold fish was shown to be wrong by the MythBusters. These examples indicate that many people don't understand the importance of research and that even scientists don't. However, even seemingly pointless research can illuminate our understanding of the world. People love to know nearly pointless facts. This also ties back to the my first point above, we never know when something seemingly useless can suddenly have an importance beyond the scope of the original study. It may save lives. That finding about fishes could help build better large scale aquariums where it is safer to interact with dangerous fish, like killer whales and sharks.
My final point is that some basic research will not be conducted by industry players. There's no guarantee on any return on some scientific investigation. However, it can be incredibly important for the advancement of industry. Quantum computing could be the next big thing for computing, however it's being researched by a combination of industry and universities. Most of the money and risk is on the university side though. Our understanding of particle physics helps us understand how quantum computing can help. Eventually we may be able to use this neutrino finding, if it pans out, in communication systems. There's no reason why we wouldn't be able to use the spin of a neutrino to transmit information.
Seemingly frivolous research is an important part of the scientific process. Enjoy it.
Friday, August 5, 2011
Ethics in Science III
I've been doing a series on Ethics in science, part one, part two, because there's been a lot of public issues in the UK about the behavior of scientists. Any suggestions, or laws put into affect would have far reaching impacts. As any scientist in the UK would be required to follow them and any scientist that wishes to publish in a journal headquartered there. I believe Nature is. Nature is THE journal to get published in.
There are some different suggestions on what should be done, including ethics review boards and independent verification of results. The UK's investigation of fraud led to this result:
However, then we come to medical sciences. Here there are much greater incentives to commit fraud or intentionally mislead. Why? Well, for a blockbuster drug they can sell Billions in revenue a year. If a drug company thinks that they have a blockbuster on their hands they will try to get it to market sooner. In most cases they have patent protection for at most 10 to 15 years. But you've said patents are for 20 years. That's true, however, it typically takes drug companies 10 years to get a drug to market. After the last ten years they are able to request a 5 year extension.
Why is the system set up like this? Well, the drug companies test a lot of different drugs and not all of them can be blockbuster drugs. A lot of them don't make it through the rigorous testing process either. The drug companies have to pay for all of that as well as make a profit. So, they charge a lot for these blockbuster drugs. They actually do have some different prices to try to help the poor out as well though.
So, in clinical trails there is more incentive to commit fraud or with hold important results. What can be done about it? Well Bernie Sanders (US Senator) has proposed a prize competition for developing different kinds of drugs, which as a stipulation of getting the prize the US government would own the patent. The government would license the patent out so drugs could be cheaper. However, this prize would have to be huge which would again provide more incentives to defraud the government. It would have to be in the billions to allow for the drug companies to recoup their expenses. It could force much stronger restrictions and oversight on the drug trials though. Which could reduce the ability to commit fraud. The prize committee could potentially be made up of scientists that are part of the NIH (National Institute of Health) which would do the data analysis for each of the "Blockbuster" trials thus forcing impartiality into clinical trials.
This could work. Additionally there could be sanctions put on the fraudulent authors, where they are unable to publish for a year, at any level. Where they lose their grants, or are unable to hire new graduate students until they show they have been reformed. This would certainly kill their career. However, this should happen.
Finally, I think that scientists should be required to add any conflicts of interest in the publications as well as sources of funding. In many cases this already happens as the funding agencies require it, however making it an explicit part of the publication process will make it more transparent. Transparency is vital to science.
Science isn't perfect, but it's our best tool for understanding the world around it. Committing fraud on the scientific community and the world as a whole is a horrible crime and should be treated as such.
There are some different suggestions on what should be done, including ethics review boards and independent verification of results. The UK's investigation of fraud led to this result:
In the same way that there is an external regulator overseeing health and safety, we consider that there should be an external regulator overseeing research integrity," says the committee's report. "We recommend that the government set out proposals on the scope and powers of such a regulator and consult with the research community and other relevant parties to develop them.I understand what they are going for here. They want to prevent another vaccine debacle or prevent another cold fusion lie. I think they also plan to prevent another "Climate gate." While these are noble causes, I can't help but fear that politics will get involved in this process. If a scientist is found of committing true fraud their career is over. There just isn't the right incentives to commit fraud in MOST sciences. Yes, it happens, but it's more likely to be a mistake than true fraud. Which is something that peer review might catch. However, even this is difficult without the initial data set, or recordings of how the experiment was carried out. Scientists are pretty brutal when going through the peer review process. They question everything and you have to have a satisfactory answer to all their questions if you want the results to be published. The true best way to improve scientific debate is to provide incentives to publish articles that have debunked previous research. This will fix more problems than a regulatory board for most of the sciences.
However, then we come to medical sciences. Here there are much greater incentives to commit fraud or intentionally mislead. Why? Well, for a blockbuster drug they can sell Billions in revenue a year. If a drug company thinks that they have a blockbuster on their hands they will try to get it to market sooner. In most cases they have patent protection for at most 10 to 15 years. But you've said patents are for 20 years. That's true, however, it typically takes drug companies 10 years to get a drug to market. After the last ten years they are able to request a 5 year extension.
Why is the system set up like this? Well, the drug companies test a lot of different drugs and not all of them can be blockbuster drugs. A lot of them don't make it through the rigorous testing process either. The drug companies have to pay for all of that as well as make a profit. So, they charge a lot for these blockbuster drugs. They actually do have some different prices to try to help the poor out as well though.
So, in clinical trails there is more incentive to commit fraud or with hold important results. What can be done about it? Well Bernie Sanders (US Senator) has proposed a prize competition for developing different kinds of drugs, which as a stipulation of getting the prize the US government would own the patent. The government would license the patent out so drugs could be cheaper. However, this prize would have to be huge which would again provide more incentives to defraud the government. It would have to be in the billions to allow for the drug companies to recoup their expenses. It could force much stronger restrictions and oversight on the drug trials though. Which could reduce the ability to commit fraud. The prize committee could potentially be made up of scientists that are part of the NIH (National Institute of Health) which would do the data analysis for each of the "Blockbuster" trials thus forcing impartiality into clinical trials.
This could work. Additionally there could be sanctions put on the fraudulent authors, where they are unable to publish for a year, at any level. Where they lose their grants, or are unable to hire new graduate students until they show they have been reformed. This would certainly kill their career. However, this should happen.
Finally, I think that scientists should be required to add any conflicts of interest in the publications as well as sources of funding. In many cases this already happens as the funding agencies require it, however making it an explicit part of the publication process will make it more transparent. Transparency is vital to science.
Science isn't perfect, but it's our best tool for understanding the world around it. Committing fraud on the scientific community and the world as a whole is a horrible crime and should be treated as such.
Thursday, August 4, 2011
Ethics in Science II
Yesterday I discussed some of the ethical concerns within the Medical science field. This case most likely has the most frequent cases of fraud and unethical behavior. Why? Because there's a ton of money involved. Clinical trials relate to drugs, which is a multibillion dollar industry. Additionally, there is no requirement by the National Institute of Health to list any potential conflicts of interest. According to Nature there was a plan in the works to require this. However, it got scuttled. In business people go to jail for these types of things.
However, medical science is not the only place where fraud happens. As this ethic blog notes there are a lot of several different kinds of fraud. Some are intentional, others are less intentional. The biggest problem is intentional fraud. Where the author makes up some result. There are two pretty big examples of this. The first is the fake human clone from South Korea by a scientists named Dr. Hwang Woo Suk. This guy was rather quickly outed as a fraud. However, this wasn't until there was a HUGE debate in the mainstream media about the ethics of cloning human stem cells. This helped push the US and much of Europe to ban cloning of human embryos.
The second most famous case of fraud is the case of cold fusion. What is cold fusion though, why would people want to make claims of making that happen? Well, fusion is what the sun does, if we could manage to do that on earth without burning ourselves up that would be pretty awesome. Basically, as the PopSci article states, is that with fusion you get more energy than what you put into it. It basically would solve all world energy problems. The first person that does it would basically be a savior to the human race. So, it's something that people really want to do. There's debate if it's even possible, it's theoretically possible, but physically possible is still up for debate.
So, accidental fraud comes about from introducing a personal bias or from misinterpreting data. Both of these happen fairly often in science. Why? because we're human, and this is what the scientific method is supposed to eliminate over time. Before publishing results you typically need to have been able to reproduce them and show that there is a trend that is consistent over time for the phenomena that you are studying. This is one of the biggest requirements for science. Which is why in clinical trials there are at least three stages to ensure repeatability of the data.
The other good thing about the scientific method is the fact that other people can take your results and findings and test them. IF the results are different they can be published and used to dispute the previous findings. This happens all the time in regular scientific discourse. In fact there's a great example of this going on right now. This debate has been going on for about a hundred years now or so. Recently a group debunked Gould's bias argument. Basically a guy back in the late 1800's measured a big set of skulls to see if there were any size differences. Stephen Jay-Gould, basically the Richard Dawkins of his day, re-analyzed the data because he felt there was bias in it, and found that there was in fact bias! Well, this recent group actually remeasured the skulls and found out that it was Gould that was biased and that if anything the original sample was more correct.
Science is supposed to be totally objective. As we can see from this discussion it's not, and cannot be. Why? We're human. However, the system works really well as a whole. In my next blog I'll discuss some of the ways we can address issues of fraud other concerns that I've mentioned over the past two days.
However, medical science is not the only place where fraud happens. As this ethic blog notes there are a lot of several different kinds of fraud. Some are intentional, others are less intentional. The biggest problem is intentional fraud. Where the author makes up some result. There are two pretty big examples of this. The first is the fake human clone from South Korea by a scientists named Dr. Hwang Woo Suk. This guy was rather quickly outed as a fraud. However, this wasn't until there was a HUGE debate in the mainstream media about the ethics of cloning human stem cells. This helped push the US and much of Europe to ban cloning of human embryos.
The second most famous case of fraud is the case of cold fusion. What is cold fusion though, why would people want to make claims of making that happen? Well, fusion is what the sun does, if we could manage to do that on earth without burning ourselves up that would be pretty awesome. Basically, as the PopSci article states, is that with fusion you get more energy than what you put into it. It basically would solve all world energy problems. The first person that does it would basically be a savior to the human race. So, it's something that people really want to do. There's debate if it's even possible, it's theoretically possible, but physically possible is still up for debate.
So, accidental fraud comes about from introducing a personal bias or from misinterpreting data. Both of these happen fairly often in science. Why? because we're human, and this is what the scientific method is supposed to eliminate over time. Before publishing results you typically need to have been able to reproduce them and show that there is a trend that is consistent over time for the phenomena that you are studying. This is one of the biggest requirements for science. Which is why in clinical trials there are at least three stages to ensure repeatability of the data.
The other good thing about the scientific method is the fact that other people can take your results and findings and test them. IF the results are different they can be published and used to dispute the previous findings. This happens all the time in regular scientific discourse. In fact there's a great example of this going on right now. This debate has been going on for about a hundred years now or so. Recently a group debunked Gould's bias argument. Basically a guy back in the late 1800's measured a big set of skulls to see if there were any size differences. Stephen Jay-Gould, basically the Richard Dawkins of his day, re-analyzed the data because he felt there was bias in it, and found that there was in fact bias! Well, this recent group actually remeasured the skulls and found out that it was Gould that was biased and that if anything the original sample was more correct.
Science is supposed to be totally objective. As we can see from this discussion it's not, and cannot be. Why? We're human. However, the system works really well as a whole. In my next blog I'll discuss some of the ways we can address issues of fraud other concerns that I've mentioned over the past two days.
Wednesday, August 3, 2011
Ethics in Science
So, right now the UK is in a big uproar about ethics in science. There have been parliamentary hearings which have deeply concerned scientists. In one opinion piece from the guardian the author argues that it's been too long going that the scientific community has been able to function without some sort of regulation. Scientists of course object to this. Because there is a method to the manner in which they work. Many, from the tone at the hearings, feel this is another assault on the scientific community.
However, it maybe that there's some scientific work that is more likely to have fraudulent activity in it. Today the Guardian published an article about scientific ghost writers. Scientific Ghost writers can come in two forms. The first is harmless where the author is really the person that got the funding. Depending on the journal these authors are either the second or very last author on the paper. This is normal, as typically you're working in that person's lab and they are paying you. So they should get some credit for the work done as they may also have had an advising role. The second kind of ghost writing is much worse. These writers were in no way associated with the research and their names are put on the article to give it weight, or if they were the ones supposed to be doing the research and some one else did it. In the Guardian article they are focusing on clinical trials for medicines.
This isn't the only country where fraud, exaggerating claims or ghost writing occurs. Although, the UK has had one of the most famous cases with the retracted article linking MMR vaccine to Autism (meaning it was fraud). This also happens in the US and in many clinical trials. In fact a Greek doctor has made it his mission to unearth clinical trial fraud and really understand what was going on there. The Atlantic had a great write up about this in November of 2010. The doctor Ioannidis has been making a career out of debunking claims as well as researching the causes of these problems. He argues that the double blind clinical trial isn't giving us the best results we could possibly be getting in medical science. Although, he doesn't offer a huge amount of alternatives.
The New York Times also ran a story about in September of last 2010 about some of the ethics behind clinical trials. This article discusses how two cousins ended up in the same trial and one cousin was given the treatment and the other was not. It was a story that was really questioning the ethics of the clinical trial, because it was obviously working. However, pushing through these treatments without fulling testing them can be just as dangerous. Granted these people were near the end as it was. The cousin that didn't receive the new treatment died from only getting the chemo.
One the one hand we want to get promising medicine out as fast as possible. However, we want to ensure we are properly testing these medicines to ensure safety. This leads to a great deal of ethical concerns. For promising medicines do we make exceptions? Do we allow fully untested medicine into the wild? These are difficult questions. From an ethical and moral standpoint allowing a patient to die because of a randomized test is very questionable, which is what happened in the case above. However, in some cases rushing through medicines like these end up causing deaths in other manners. In the case of Vioxx this is exactly what happened. In many people it reduced the risk while in others it out right killed them. Where is the balance? I think this is why the UK is pushing for more oversight in these cases.
*Note: my dad, a nurse practitioner pointed out that i was slightly wrong about Vioxx. He's correct. There were more ethical problems than the fact it was a bad drug. Simply the creators of Vioxx hid the fact that it impacted african americans differently than white americans. If Vioxx hadn't done this it wouldn't have been a problem for the drug to stay on the market. If you want to read more about Vioxx there's a chapter in the book Denialism By Michael Specter
In my next blog I'll discuss scientific fraud and ethics in other fields.
However, it maybe that there's some scientific work that is more likely to have fraudulent activity in it. Today the Guardian published an article about scientific ghost writers. Scientific Ghost writers can come in two forms. The first is harmless where the author is really the person that got the funding. Depending on the journal these authors are either the second or very last author on the paper. This is normal, as typically you're working in that person's lab and they are paying you. So they should get some credit for the work done as they may also have had an advising role. The second kind of ghost writing is much worse. These writers were in no way associated with the research and their names are put on the article to give it weight, or if they were the ones supposed to be doing the research and some one else did it. In the Guardian article they are focusing on clinical trials for medicines.
This isn't the only country where fraud, exaggerating claims or ghost writing occurs. Although, the UK has had one of the most famous cases with the retracted article linking MMR vaccine to Autism (meaning it was fraud). This also happens in the US and in many clinical trials. In fact a Greek doctor has made it his mission to unearth clinical trial fraud and really understand what was going on there. The Atlantic had a great write up about this in November of 2010. The doctor Ioannidis has been making a career out of debunking claims as well as researching the causes of these problems. He argues that the double blind clinical trial isn't giving us the best results we could possibly be getting in medical science. Although, he doesn't offer a huge amount of alternatives.
The New York Times also ran a story about in September of last 2010 about some of the ethics behind clinical trials. This article discusses how two cousins ended up in the same trial and one cousin was given the treatment and the other was not. It was a story that was really questioning the ethics of the clinical trial, because it was obviously working. However, pushing through these treatments without fulling testing them can be just as dangerous. Granted these people were near the end as it was. The cousin that didn't receive the new treatment died from only getting the chemo.
One the one hand we want to get promising medicine out as fast as possible. However, we want to ensure we are properly testing these medicines to ensure safety. This leads to a great deal of ethical concerns. For promising medicines do we make exceptions? Do we allow fully untested medicine into the wild? These are difficult questions. From an ethical and moral standpoint allowing a patient to die because of a randomized test is very questionable, which is what happened in the case above. However, in some cases rushing through medicines like these end up causing deaths in other manners. In the case of Vioxx this is exactly what happened. In many people it reduced the risk while in others it out right killed them. Where is the balance? I think this is why the UK is pushing for more oversight in these cases.
*Note: my dad, a nurse practitioner pointed out that i was slightly wrong about Vioxx. He's correct. There were more ethical problems than the fact it was a bad drug. Simply the creators of Vioxx hid the fact that it impacted african americans differently than white americans. If Vioxx hadn't done this it wouldn't have been a problem for the drug to stay on the market. If you want to read more about Vioxx there's a chapter in the book Denialism By Michael Specter
In my next blog I'll discuss scientific fraud and ethics in other fields.
Tuesday, July 5, 2011
Controversies III - Evolution
So, we have some ideas for how to deal with climate change. Will they work? I don't know. I hope my friends that read my last post will discuss will educate themselves on climate change and work to talk with their friends about it. Also, let me know if you do and how it goes!
How do we deal with evolution though? This one is a lot trickier, not that dealing with climate change is easy (but I think my idea is a step in the right direction). People who are much smarter than I am have been attempting to tackle this one for some time, including Richard Dawkins who is extremely knowledgeable about the topic. He wrote a fantastic book about evolution called "The greatest show on Earth" where he discusses each of the "counter" claims of ID (Intelligent design) advocates.
However, in some ways this is even besides the point. The major issue is that people are trying to remove evolution from the classroom. This is the biggest problem. This would destroy our capabilities to compete in the future in biomedical applications.
Why are people trying to fight evolution? Well, they feel that it will drive people to atheism. This isn't true. There are many people that have figured out ways to reconcile their religious beliefs with evolution. The biggest problem is that it directly contradicts the bible. Which in the US there is a growing minority that take the bible literally. The next issue is the growing minority that falsely claim the US is a "Christian Nation" which this CNN contributor debunks.
It appears that we need to not just worry about scientific accuracy but also historical. For it is impossible to really understand the "controversy" without understanding the context that it is being framed within. Without this claimed backdrop there would be no basis under which to fight having evolution in school classes. Evolution is not a religion. With the pope accepting it, it's as much of a part of catholicism as it is part of secular humanism or part of the accepted scientific facts of an atheist. Since the supporters of ID place the argument within this framework though we must first refute the framework of a christian nation and from there we can show that it is impossible to teach ID in school while evolution must be taught in school.
Additional ponderable thoughts:
"Nothing in Biology Makes Sense Except in the Light of Evolution" is a 1973 essay by the evolutionary biologist and Russian Orthodox Christian Theodosius Dobzhansky, criticising anti-evolution creationism and espousing theistic evolution. The essay was first published in the American Biology Teacher, volume 35, pages 125-129. (Wikipedia)
We teach our vets, doctors, nurses and pharmacists biology. Without a clear understanding of biology from a young age the quality of our healthcare can only go down. As a country we will not be able to stay on top of the life sciences research and pharmaceutical production.
If we fail to education our students on biology how do we keep up, and how to we keep our economy running?
How do we deal with evolution though? This one is a lot trickier, not that dealing with climate change is easy (but I think my idea is a step in the right direction). People who are much smarter than I am have been attempting to tackle this one for some time, including Richard Dawkins who is extremely knowledgeable about the topic. He wrote a fantastic book about evolution called "The greatest show on Earth" where he discusses each of the "counter" claims of ID (Intelligent design) advocates.
However, in some ways this is even besides the point. The major issue is that people are trying to remove evolution from the classroom. This is the biggest problem. This would destroy our capabilities to compete in the future in biomedical applications.
Why are people trying to fight evolution? Well, they feel that it will drive people to atheism. This isn't true. There are many people that have figured out ways to reconcile their religious beliefs with evolution. The biggest problem is that it directly contradicts the bible. Which in the US there is a growing minority that take the bible literally. The next issue is the growing minority that falsely claim the US is a "Christian Nation" which this CNN contributor debunks.
It appears that we need to not just worry about scientific accuracy but also historical. For it is impossible to really understand the "controversy" without understanding the context that it is being framed within. Without this claimed backdrop there would be no basis under which to fight having evolution in school classes. Evolution is not a religion. With the pope accepting it, it's as much of a part of catholicism as it is part of secular humanism or part of the accepted scientific facts of an atheist. Since the supporters of ID place the argument within this framework though we must first refute the framework of a christian nation and from there we can show that it is impossible to teach ID in school while evolution must be taught in school.
Additional ponderable thoughts:
"Nothing in Biology Makes Sense Except in the Light of Evolution" is a 1973 essay by the evolutionary biologist and Russian Orthodox Christian Theodosius Dobzhansky, criticising anti-evolution creationism and espousing theistic evolution. The essay was first published in the American Biology Teacher, volume 35, pages 125-129. (Wikipedia)
We teach our vets, doctors, nurses and pharmacists biology. Without a clear understanding of biology from a young age the quality of our healthcare can only go down. As a country we will not be able to stay on top of the life sciences research and pharmaceutical production.
If we fail to education our students on biology how do we keep up, and how to we keep our economy running?
Friday, June 10, 2011
But it's JUST a theory.
The point of this post is not to defend evolution, but to investigate the different meanings behind the word theory. However, this point comes up most frequently when people discussion evolution and possibly climate change. The word theory has become a very loaded word during discussions between scientists and non-scientists. It causes scientists to come across as arrogant to non-scientists. What causes people to believe that these scientists are arrogant? Well in Professor Dawkin's documentary "Root of all Evil" Ted Haggard claims it has to do with how certain scientists are about their "theories." Where scientists look down upon non-scientists in their ignorant views. For science this is a dangerous proposition where the people scientists need to convince the most that many different forms of scientific research needs to be conducted and funded publicly, scientists come across as arrogant know it alls that refuse to explain anything to the common person. This has also been noted in a Pew Science Survey.
So, why are scientists "arrogant" about their "theories?" Well, first it's not arrogance. It's extreme confidence in the current understanding of the world. The "theories" describe the state of the world and how we interact with it. However, there is a misunderstanding about the word theory. This can come from two ways. First, intentional intellectual dishonesty. In this case there is not much to be done, other than attempt to bring out this fraud and discredit the person on this basis. The second is an honest misunderstanding of the word. This may be difficult for many scientists to actually believe, but I think this can legitimately happen. While people who are actively interested in science are constantly being refreshed and reminded of how science works why it works and all the great things it has done for us, people who aren't interest forget these things. Many of them haven't had a refresher on how science works since high school, and that's if they were paying attention to their teacher. They believe that a theory is a general idea of how something works, a educated guess.
I plan to elaborate on the differences in definitions through using a model presented through psychology in 1986. The study claims there are folk theories on how technology works, specifically thermostats. It is clear that there is the correct "scientific" theory of how the thermostat works, so it will be easy to compare the differences in the two different thermostat theories.
Willet Kempton's article "Two theories of home heat control" is a survey of residents of Detroit Michigan of how the thermostat works in their house. The survey shows two prevailing theories. The valve theory and the feedback theory. The feedback theory is fairly straight forward, the thermostat detects the temperature and either turns on or off the furnace based on the deviation from the set temperature. The valve theory is a little different, this theory claims that when you turn up the thermostat you are increasing the flow of hot air the furnace is producing, which will increase the rate the house warms up. There maybe some reasons why this theory was popular, the fact that the thermostat was a knob and that many people were used to using radiators to heat their house previously. These two theories were defined as "Folk Theories" which fall into the general category of educated guess or a hunch of how it works.
However, we know that both of these cannot be correct. So at this point we have competing paradigms or research programs. So to determine which one is correct we conduct experiments. We collect temperature data of the air coming from the ventilator at various different thermostat settings. This allows us to test our hypothesis that the thermostat is actually a valve. Since the feedback theory is basically correct our data would show that the temperature of the air is constant or near constant regardless of the temperature setting on the thermostat.
Now we can move onto test the theory of the feedback mechanism. We can create more sophisticated tests to determine what the on/off points are for the furnace and create a model of how the thermostat interacts with the furnace to maintain the heat in a house. Over time we can build confidence in our model and other people can test our model in their own home and check the validity.
When people accept this model based on empirical evidence we then can say we have a scientific theory. However, this theory, while it may have been formed from a folk theory, has been thoroughly tested and replicated by many individuals. We can find many different examples of this in science, from biology, theories of gravity, relativity, the origin of the world, the list goes on and on.
Folk theories are hunches and educated guesses. Scientific theories are verifiable, testable and may be contradictory to our personal intuition.
So, why are scientists "arrogant" about their "theories?" Well, first it's not arrogance. It's extreme confidence in the current understanding of the world. The "theories" describe the state of the world and how we interact with it. However, there is a misunderstanding about the word theory. This can come from two ways. First, intentional intellectual dishonesty. In this case there is not much to be done, other than attempt to bring out this fraud and discredit the person on this basis. The second is an honest misunderstanding of the word. This may be difficult for many scientists to actually believe, but I think this can legitimately happen. While people who are actively interested in science are constantly being refreshed and reminded of how science works why it works and all the great things it has done for us, people who aren't interest forget these things. Many of them haven't had a refresher on how science works since high school, and that's if they were paying attention to their teacher. They believe that a theory is a general idea of how something works, a educated guess.
I plan to elaborate on the differences in definitions through using a model presented through psychology in 1986. The study claims there are folk theories on how technology works, specifically thermostats. It is clear that there is the correct "scientific" theory of how the thermostat works, so it will be easy to compare the differences in the two different thermostat theories.
Willet Kempton's article "Two theories of home heat control" is a survey of residents of Detroit Michigan of how the thermostat works in their house. The survey shows two prevailing theories. The valve theory and the feedback theory. The feedback theory is fairly straight forward, the thermostat detects the temperature and either turns on or off the furnace based on the deviation from the set temperature. The valve theory is a little different, this theory claims that when you turn up the thermostat you are increasing the flow of hot air the furnace is producing, which will increase the rate the house warms up. There maybe some reasons why this theory was popular, the fact that the thermostat was a knob and that many people were used to using radiators to heat their house previously. These two theories were defined as "Folk Theories" which fall into the general category of educated guess or a hunch of how it works.
However, we know that both of these cannot be correct. So at this point we have competing paradigms or research programs. So to determine which one is correct we conduct experiments. We collect temperature data of the air coming from the ventilator at various different thermostat settings. This allows us to test our hypothesis that the thermostat is actually a valve. Since the feedback theory is basically correct our data would show that the temperature of the air is constant or near constant regardless of the temperature setting on the thermostat.
Now we can move onto test the theory of the feedback mechanism. We can create more sophisticated tests to determine what the on/off points are for the furnace and create a model of how the thermostat interacts with the furnace to maintain the heat in a house. Over time we can build confidence in our model and other people can test our model in their own home and check the validity.
When people accept this model based on empirical evidence we then can say we have a scientific theory. However, this theory, while it may have been formed from a folk theory, has been thoroughly tested and replicated by many individuals. We can find many different examples of this in science, from biology, theories of gravity, relativity, the origin of the world, the list goes on and on.
Folk theories are hunches and educated guesses. Scientific theories are verifiable, testable and may be contradictory to our personal intuition.
Thursday, June 9, 2011
What is Science?
In my first two post I haven't really touched on any of the three main points of my blog. So, i'm going to start from the beginning with what I mean by science. Science to me is the searching for an understanding of the natural world using rigorous tests to validate the data. This is a bit vague as I don't define on which side the hypothesis needs to be formed. In most cases, if you remember the scientific method, the hypothesis is formed first and then it is tested. This is true for the most part. However, some times you have the data first and you have to get an understanding of the data before you can do that. Once you understand the data you are free to create hypotheses where you use the given data to test these hypotheses.
There is a great deal of debate over how science actually functions. There are three main philosopher's of science, Thomas Kuhn, Imre Lakatos and Richard Feynman. The first two are basically related to creating paradigms or "research programs" which are similar but slightly different than paradigms. Basically a paradigm is something like Newtonian physics. This had a large set of assumptions and rules that were both confirmed by the data and had issues with the data. For instance Newtonian physics couldn't explain the motion of Mercury. So, there is a shift from one paradigm to the next through a revolution. Basically, the support for the first paradigm is so degraded it gives way and another one replaces it. In the case of Newtonian physics it was replaces with relativistic physics, based on Einsteinian principles. Research programs are similar but more than one can be going on at the same time. You could say string theory and m-theory, which are very similar and part of each other, but some people support only string theory and don't agree with m-theory, while supporting m-theory means you support all of string theory, but there are also people that reject both theories. The large hadron collider is being used to test these theories.
I think science does have radical shifts between major though processes and it can be very disorientating for people within the field. They tend to fight these changes, as we all do. They are human.
Regardless, I feel that science illuminates truths of how this world works and improves the human condition. While it may not always directly intend to do this, there are spill over effects that make this happen. Astronomy is a science that in no way directly impacts humanity (unless they find an asteroid that will hit earth or alien life) there have been spill overs that have made life better for people.
Science is a noble pursuit that does have ambitions larger than itself. It attempts to be the fully objective observer, but it's not completely. However, it's the best thing we have. It will continue to get better the more we do it. It has created wonders for us, and I for one am deeply indebt to all the scientists out there. Thank you for your hard work and helping me appreciate the wonders of the world.
There is a great deal of debate over how science actually functions. There are three main philosopher's of science, Thomas Kuhn, Imre Lakatos and Richard Feynman. The first two are basically related to creating paradigms or "research programs" which are similar but slightly different than paradigms. Basically a paradigm is something like Newtonian physics. This had a large set of assumptions and rules that were both confirmed by the data and had issues with the data. For instance Newtonian physics couldn't explain the motion of Mercury. So, there is a shift from one paradigm to the next through a revolution. Basically, the support for the first paradigm is so degraded it gives way and another one replaces it. In the case of Newtonian physics it was replaces with relativistic physics, based on Einsteinian principles. Research programs are similar but more than one can be going on at the same time. You could say string theory and m-theory, which are very similar and part of each other, but some people support only string theory and don't agree with m-theory, while supporting m-theory means you support all of string theory, but there are also people that reject both theories. The large hadron collider is being used to test these theories.
I think science does have radical shifts between major though processes and it can be very disorientating for people within the field. They tend to fight these changes, as we all do. They are human.
Regardless, I feel that science illuminates truths of how this world works and improves the human condition. While it may not always directly intend to do this, there are spill over effects that make this happen. Astronomy is a science that in no way directly impacts humanity (unless they find an asteroid that will hit earth or alien life) there have been spill overs that have made life better for people.
Science is a noble pursuit that does have ambitions larger than itself. It attempts to be the fully objective observer, but it's not completely. However, it's the best thing we have. It will continue to get better the more we do it. It has created wonders for us, and I for one am deeply indebt to all the scientists out there. Thank you for your hard work and helping me appreciate the wonders of the world.
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